Can Clitoral Nerve Damage Be Repaired

New method of repairing damage to optic nerve offers promise for people with glaucoma-related sight loss

Fight for Sight funded researchers accept successfully demonstrated a new method of repairing damage to the optic nerve in the lab for the first time, in new research that hopes to restore vision to those who've lost it as a result of glaucoma and other conditions.

Image shows Professor Keith Martin in scrubs

The study, which was published in Nature Communications this month, saw researchers funded by eye research charity Fight for Sight based at University of Cambridge collaborate with colleagues in Australia. The team were investigating if the gene responsible for the product of a protein known every bit protrudin, a and so-chosen 'scaffolding molecule', could help forbid or even repair damage to retinal cells caused by glaucoma.

Researchers, led past Professor Keith Martin, Dr Richard Eva, Dr Veselina Petrova and Professor James Fawcett, used a cell civilization organization to grow brain cells in a dish. They then used a laser to injure the cells' nervus fibers (axons) and analysed the response to this injury using a fourth dimension lapse microscope and found that increasing the amount of protrudin in these nervus cells vastly increased their ability to repair themselves. The protrudin was delivered to the cells using a gene therapy technique.

Glaucoma is the proper name for a group of eye weather condition that crusade sight loss because of impairment to the optic nerve – the nerve that connects the eyes to the brain. Prior to this written report, at that place was no treatment that allowed for damage to the optic nervus to be reversed. Around 500,000 people are living with glaucoma in the Great britain and it'due south the second leading cause of blindness in the world.

Despite all currently available treatments, effectually 10-15% of patients with glaucoma become blind in at to the lowest degree one eye during their lifetime. Not only could this research be effective in halting or reversing the damage caused past glaucoma, it could as well be hugely important in improving success rates of eye transplants – helping a transplanted middle to connect to the brain past growing axons through the optic nerve."

Professor Keith Martin

The findings of this research are incredibly promising – not just for people with glaucoma-related sight loss, only besides more broadly in the example of sight loss every bit a result of harm to the optic nervus. Professor Martin and his team'southward piece of work represents a significant breakthrough for centre research and the potential of regenerative medicine to observe new treatments for preventing as well as reversing sight loss."

Dr Neha Issar-Brownish, Director of Research, Fight for Sight

It's hoped that this promising research volition be followed past clinical trials in the next few years. If successful, the researchers hope this arroyo could get part of a new treatment strategy to repair the optic nerve in severe glaucoma over the side by side decade.

Source:

Journal reference:

Petrova, V., et al. (2020) Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS. Nature Communications. doi.org/10.1038/s41467-020-19436-y.

Posted in: Medical Research News | Medical Condition News

Tags: B Cell, Blindness, Brain, Jail cell, Cell Culture, Clemency, Eye, Cistron, Cistron Therapy, Glaucoma, Medicine, Microscope, Molecule, Nerve, Protein, Research, T-Cell

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